- Life & Medical Sciences
Dr. Koldo Aldámiz-Echevarría (Advisor researcher) (0034) 94 600 6327 luisjose.aldamiz-echevarazuara@osakidetza.net
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The Metabolomics/Proteomics facility is among the research support facilities of Biocruces Bizkaia Institute.
The aim of this facility is to provide the equipment, technical assistance and specialised training necessary to measure specific markers of inborn errors of metabolism, as well as search for new diagnostic and prognostic markers, to help improve our understanding of metabolic disorders and other related conditions.
The following equipment is currently available in this facility:
- Gas chromatography system with flame ionization detector [Agilent 7890 GC FID]
- A high performance liquid chromatography system coupled to a triple quadrupole (QqQ) mass spectrometry system [Agilent 1100 series-Agilent 6410 QQQ]
- Gas chromatography system coupled to a mass spectrometry system [Agilent 5990 GC-Agilent 6410 MSD]
- Ion exchange chromatography-based amino acid analyser [Biochrom 30]
- Ultraviolet–visible spectroscopy system [HP 8453]
- Microplate fluorometer
- Glucosaminoglicanos - Espectrofotometría/OR
- Complejo HCII-T (MPS I, II y VI) - ELISA/SR, SP
- Heparán sulfato - ELISA/PL,SR
- Perfil ácidos grasos (totales y fracciones) - GC-FID/PL, HEM, TEJIDO
- Perfil de acilcarnitinas - HPLC-MS/MS/SP
- Carnitina libre/total - Espectrofotometría/PL, OR
- Perfil de ácidos orgánicos y acilglicinas - GC-MS/OR
- Ácido metilmalónico - GC-MS/OR
- Ácido glutárico y 3-OH glutárico - GC-MS/OR
- Ácido 3-OH propiónico y metilcítrico - GC-MS/OR
- Perfil de aminoácidos - Cromatografía iónica/PL, OR, LCR
- Arginina y dimetilargininas (ADMA,SDMA, NMMA) - HPLC-MS/MS/PL, OR
- Test de sobrecarga de BH4 (Phe y Tyr) - HPLC-UV/PL
- Creatina/guanidinoacetato - HPLC-MS/MS/PL, OR
- Creatinina - HPLC-MS/MS / PL, OR
- Nitisinona (NTBC) HPLC-MS/MS / PL, SP
- S-adenosilmetionina (SAM) y S -adenosilhomocisteína (SAH)
- Tipificación de glucosaminoglicanos (GAGs)
- Cribado neonatal (acilcarnitinas)
- Cribado básico de enf. metabólicas (aminoácidos/ácidos orgánicos/acilcarnitinas)
- Actividad enzimática MPS I (alfa-iduronidasa) / SP
- Actividad enzimática MPS II (iduronato-2-sulfatasa) / SP
- Actividad enzimática MPS VI (arilsulfatasa B) / SP
- Actividad enzimática Fabry (alfa-galactosidasa A) / SP
- Actividad enzimática Gaucher (beta-glucosidasa) / SP
- Actividad enzimática MPS I (alfa-iduronidasa) / SP
- Actividad enzimática MPS II (iduronato-2-sulfatasa) / SP
- Actividad enzimática MPS VI (arilsulfatasa B) / SP
- Actividad enzimática Fabry (alfa-galactosidasa A) / SP
- Actividad enzimática Gaucher (beta-glucosidasa) / SP
Hospital Universitario Cruces. Plaza de Cruces 12, 48903. Barakaldo, Bizkaia (País Vasco)