Multiple Sclerosis Research groups

Strategic Objectives

  • Epidemiological register of multiple sclerosis.
  • Genetic association studies.
  • Understanding how attacks and remyelination occur. Characterisation of the transcriptome and its regulation by means of microRNA in the different stages of a disease.
  • Studies of the involvement of microparticles on MS.
  • Development of prognostic markers (gene expression, neuroimaging, biochemistry and immunology) and treatment markers.

Main lines of research

From the beginning, we have focused our research on DNA analysis in order to search for susceptibility polymorphisms which may have an influence on the risk of suffering a disease, or on the progression of the disease in question. The natural evolution of these lines of research has led us to focus more specifically on gene expression (RNA and protein) in an attempt to understand the etiology of the disease and to search for prognostic factors (biomarkers) in the blood which may help to anticipate and/or characterise the different stages of MS (attack versus non-attack).

  • Study of the factors involved in remyelination. Analysis of expression patterns on all RNA and microRNA in patients’ blood.
  • Search for outbreak biomarkers and possible treatment biomarkers.
  • Study of potential biomarkers and the biological impact of microparticles circulating in peripheral blood.
  • Validation of susceptibility SNPs.
  • Study of family aggregations.
  • Study of OCBs.
  • Potential effect of vitamin D as a co-treatment for MS.
  • Clinical characterisation of patients in the province of Gipuzkoa.
Science field

Life & Medical Sciences

Institution
Biodonostia
RIS3 Priorities
  • Biosciences & Health
Main researcher
David Otaegui
Address
Biodonostia HRI Pº Dr. Beguiristain s/n 20014 Donostia – San Sebastián Gipuzkoa
How to arrive