Basque Resource for Electron Microscopy (BREM)

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  • Physical Sciences

Dr. David Gil Carton

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Cryo-electron microscopy (cryo-EM) allows the visualisation and determination, to atomic resolution in some cases, of the structure of biological specimens (proteins, nucleic acids, macromolecular complexes, organelles, cells and tissues) in a physiological environment using specialised electron cryo-microscopes. Spectacular advances in technology and software over the last decade have propelled cryo-EM to launch a global revolution in structural biology, where the number of structures solved by cryo-EM is rapidly increasing at a quasi-exponential rate. Furthermore, due to the advantages of cryo-EM for studying large and complex cellular systems of biological and biomedical interest related to health and disease, most of these investigations have been published in high-impact journals. Consequently, high resolution cryo-EM has been incorporated into the drug discovery and development programmes of large pharmaceutical companies.

The Titan Krios Cryo-EM at the FBB is an open access research facility that provides specialized equipment in the field of cryo-electron microscopy, for both single particle analysis and cryo-tomography. BREM is supported by the Fundación Biofísica Bizkaia (FBB) and the Department of Education of the Basque Government, and hosts a Krios G4, equipped with a phase plate and Gatan BioContinuum k3 detector, as well as a large array of ancillary equipment (find out more here). 


Unidad de Biofísica (UPV/EHU, CSIC) , Barrio Sarriena. 48940 Leioa Bizkaia