- Life & Medical Sciences
Access to the unit of Radioisotopes involves meeting the requirements set forth in the Protocol for access to SGIker and the services it provides. Specific rulles / regulation also apply for this installation, please check website for further details.
The General Radioisotope Service of the University of the Basque Country/Euskal Herriko Unibersitatea is currently defined as an ionizing radiation metrology laboratory which has the equipment at its disposal required for the analysis of radioactive elements. The current structure dates back to 1990, when its installations located at the Department of Biochemistry and Molecular Biology of the Faculty of Science and Technology - at the University of the Basque Country/Euskal Herriko Unibersitatea - were first opened as an IR/BI-87/88 (IRA-1535) Third Category Radioactive Installation. It is an installation authorised by the Nuclear Safety Council for the handling of non-encapsulated radioactive sources for research and teaching purposes. The main aim of the Service is to ensure that all teaching and research activities that may entail the use of ionizing radiation be carried out with the utmost guarantees in terms of safety and protection, and always within the legal scope established. In accordance with the relevant resolutions applied to General Services at the University of the Basque Country, the structure of the GENERAL RADIOISOTOPE SERVICE comprises the following units, which are attached to each other: The Isotopic Analysis Laboratory, which provides the Service with the capacity to handle and analyse non-encapsulated radiation with radioactive environmental contamination. The Radioactivity Meter Room, which complements the above-mentioned unit and via which the capacity has been created to carry out radiation metrology and the characterization of radioactive sources in general. Warehouse for radioactive residues of non-encapsulated sources. This General Service attempts to meet the ample demand both on the part of research groups from the different departments of the University of the Basque Country/Euskal Herriko Unibersitatea, technology centres from the Basque Autonomous Community and public and private companies, who have expressed the need to accurately find out the concentrations of radioisotopes in biological clinical and research samples. The installation, located in the basement of building CD4 of the Faculty of Science and Technology, is authorised to handle the following non-encapsulated radioisotopes, the maximum activities of which that may be stored at the installation are: Isotopes - Maximum activity Iodine-125 (125I) 9,2 MBq (0,25 mCi) Rubidium-86 (86Rb) 37 MBq (1 mCi) Calcium-45 (45Ca) 37 MBq (1 mCi) Phosphorus-32 (32P) 37 MBq (1 mCi) Carbon-14 (14C) 37 MBq (1 mCi) Tritium (3H) 370 MBq (10 mCi) Zinc-65 (65Zn) 37 MBq (1 mCi) Sulphur-35 (35S) 370 MBq (10 mCi) Phosphorus-33 (33P) 37 MBq (1 mCi) Iron-55 (55Fe) 37 MBq (1 mCi) Wolfram-185 (185W) 37 MBq (1 mCi)
- Monitoring of metabolytes marked in the different metabolic routes of animals, plants and microorganisms. - Study into the cell cycle and behaviour of cyclines. - Studies into the regulation of syntheses and degradation of nucleic acids and the study of gene expression using PCR techniques (Polymerase Chain Reaction). - Regulation of cell activation by proto-oncogenes and cytokines. - Control of cell proliferation and death (apoptosis/necrosis). - Determination of intracellular second messengers and the study of the different routes of cellular signalling. - Study and characterization of membrane receptors with radioligands. Detection and determination of biological molecules via commercial kits that contain radioactive isotopes. Analysis of cyclic nucleotides by radioimmunotest (RIA). Measurements of enzymatic activities.
University of the basque country UPV/EHU Science and technology faculty Radioactive instalation IRA - 1535 Barrio Sarriena, s/n 48940 Leioa (Bizkaia)