Calorimetry and thermophoresis

Áreas de investigación

Página web

Contacto

¿Disponible para usuarios externos?

Yes

Descripción

A specialized platform for the thermodynamic study of molecular interactions, thermal stability, and advanced compositional characterization of materials by monitoring changes in mass.
It uses highly sensitive techniques to measure transition enthalpies and dissociation constants (Kd) with minimal sample volumes, as well as to analyze thermal degradation under controlled atmospheres.
The platform is essential for drug design, polymer characterization, and the study of protein–ligand interactions. It provides precise data on binding affinity and heat capacity, volatile content and moisture, and the thermogravimetric stability of the systems under study.

Servicios

Binding affinity measurement (Kd): Determination of binding affinities for protein–protein and protein–ligand interactions in aqueous solutions or cell lysates using microscale thermophoresis.
Thermal analysis of materials: Measurement of heat capacities and phase transitions in thermoplastics, polymers, adhesives, and chemical compounds.
Stability studies: Assessment of the thermal stability of biological macromolecules under different solvent conditions and in mixtures.
High-resolution thermogravimetric analysis (TGA): Precise quantification of mass changes as a function of temperature or time. This technique enables the assessment of thermal stability, degradation profiles, moisture/volatile content, and the composition of biomaterials, polymers, and technical coatings.

Localización

CIC biomaGUNE

Science and Technology Park of Gipuzkoa, Miramón 194, 20014 Donostia/San Sebastián, Gipuzkoa. Spain.
Tel.: +34 943 005 300

Compartir